| Part I: Systems Microbiology - 'The Cell as a Well-stirred Bioreactor' |
| 1 |
Introduction
Michaelis-Menten Kinetics |
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| 2 |
Equilibrium Binding
Cooperativity |
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| 3 |
Lambda Phage
Multistability |
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| 4 |
Multistability (cont.) |
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| 5 |
Synthetic Genetic Switches |
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| 6 |
Stability Analysis |
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| 7 |
Introduction E. coli Chemotaxis |
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| 8 |
Fine-tuned versus Robust Chemotaxis Models |
Problem set 1 due |
| 9 |
Wrapping up Chemotaxis |
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| 10 |
Genetic Oscillators |
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| 11 |
Genetic Oscillators (cont.) |
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| 12 |
Stochastic Chemical Kinetics |
Problem set 2 due |
| 13 |
Stochastic Chemical Kinetics (cont.) |
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| Part II: Cell Systems Biology - 'The Importance of Diffusion and Gradients for Cellular Regulation' |
| 14 |
Introduction Cell Systems Biology
Fick's Laws |
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| 15 |
Local Excitation
Global Inhibition Theory |
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| 16 |
Local Excitation (cont.)
Global Inhibition Theory (cont.) |
Problem set 3 due |
| 17 |
Rapid Pole-to-pole Oscillations in E. coli |
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| 18 |
Rapid Pole-to-pole Oscillations in E. coli (cont.) |
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| 19 |
Models for Eukaryotic Gradient Sensing |
Problem set 4 due |
| 20 |
Models for Eukaryotic Gradient Sensing (cont.) |
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| 21 |
Modeling Cytoskeleton Dynamics |
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| 22 |
Modeling Cytoskeleton Dynamics (cont.) |
Problem set 5 due |
| Part III: Developmental Systems Biology - 'Building an Organism Starting From a Single Cell' |
| 23 |
Quorum Sensing |
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| 24 |
Final Problem Set Question Hour |
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| 25 |
Drosophila Development |
Take home final due |