| 1 |
Introductory Remarks, Course Requirements
Introduction to NMR
Classical Model of the NMR Phenomenon
The Bloch Equations |
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| 2 |
Relaxation Mechanisms and Measurement
Proton Relaxation Enhancement
Effects of Magnetic Susceptibility
Introduction to Pulse Sequences |
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| 3 |
Review of Rotating Frame
Spin Echos
Ernst Angle
Off-resonance Effects |
Assignment 1 due |
| 4 |
Image Contrast (T1, T2 Weighting)
Basic NMR Spectroscopy
Chemical Shifts, J-coupling
Basic Pulse Sequences in Uncoupled and Coupled Systems |
Assignment 2 due |
| 5 |
Image Encoding
Fourier Transforms and Properties
Image Resolution - Point Spread Function |
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| 6 |
Review of k-space Formalism
Review of Resolution and Sampling - Nyquist Rate
MR Image Reconstruction
Gradient and RF Waveforms |
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| 7 |
Errors in Imaging (Ghosting) |
Assignment 3 due
Midterm Quiz
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| 8 |
MRI Hardware Overview |
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| 9 |
Additional Pulse Sequences
Chemical Shift Imaging and Flow Imaging Techniques
2-D and 3-D CSI
Time of Flight and Phase Contrast Flow Imaging |
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| 10 |
Guest Lecturer - Van Wedeen, PhD
Diffusion-weighted MR Techniques |
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| 11 |
Parallel Imaging
MR Encoding Matrix Formalism
Multiple Coil Formalism
SMASH and SENSE |
Assignment 4 due |
| 12 |
Guest Lecturer - Alan Jasanoff, PhD
Molecular Imaging Techniques
Guest Lecturer - Elfar Adalsteinsson, PhD
Advanced Image Reconstruction |
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| 13 |
Guest Lecturer - Robert Savoy, PhD
Introduction to fMRI and Experiment Design |
Assignment 5 due |
| 14 |
Class Presentations |
Final Project due |