| Part I. Principles of Tissue Engineering: Scaffolds and Cells |
| 1 |
Course Overview/Clinical Problems for Tissue Engineering Solution
Introduction to Tissue Engineering in China
Scaffolds: Introduction
Scaffolds: Collagen-GAG Analogs of Extracellular Matrix |
Prof. Spector, MIT / Prof. Cui, Tsinghua University
Prof. Cui, Tsinghua University
Prof. Spector, MIT
Prof. Yannas, MIT |
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| 2 |
Cells: Liver Cells
Scaffolds: Recent Advances in Tissue Engineering |
Yingxin Xu, M. D., and Qingling Feng, Ph. D., Tsinghua University
Prof. Langer, MIT |
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| 3 |
Scaffolds: Free-Form Manufacturing
Scaffolds: Self-Assembled Proteins
Review |
Prof. Yan, Tsinghua University
Dr. S. Zhang, MIT
Prof. Spector, MIT |
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| 4 |
Cells: Sources
Cells: Differentiated versus Stem Cells |
Dr. C. Vacanti, MIT
Prof. Spector, MIT |
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| Part II. Principles of Tissue Engineering: Cells and Regulators |
| 5 |
Scaffolds: Biomimetics Design
Cells: Effects of Culture Conditions
Review |
Prof. Cui, Tsinghua University
Dr. L. Freed, MIT
Prof. Spector, MIT |
Homework 1 due |
| 6 |
Quiz 1 |
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Homework 2 due |
| 7 |
Regulators: Response to Mechanical Loading
Regulators: Roles of Environmental Factors |
Prof. Grodzinsky, MIT
Dr. Vunjak-Novakovic, MIT |
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| 8 |
Cells: Embryonic and Other Stem Cell for Tissue Engineering
Gene Therapy
Regulators: Gene Transfer Wedded to Tissue Engineering |
Prof. Guo, Tsinghua University
Dr. Zhijie Chang, Tsinghua University
Prof. Evans, Harvard Medical School |
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| Part III. Practice of Tissue Engineering: Clinical Applications |
| 9 |
Applications: Skin and Peripheral Nerve
Nerve Repair
Discussion: Clinical Applications |
Prof. Yannas, MIT
Xiufang Zhang, Nanming Zhao, Yandao Gong, Tsinghua University
Prof. Spector, MIT |
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| 10 |
Blood Vessels
Heart Valves
Discussion: Comparative Analysis of Tissue Engineering Strategies |
Prof. Schoen, Harvard Medical School
Dr. W. B. Li, Tsinghua University
Prof. Spector, MIT |
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| 11 |
Urinary Tissues/Organs
Clinical Applications and Underlying Principles |
Prof. Atala, MIT
Prof. Y. Cao, Tsinghua University |
Homework 3 due |
| 12 |
Bone Regeneration
Cartilage Repair
Discussion: Review |
Dr. Yu Xing, Tsinghua University, and Prof. Yan Wang, M. D., General Hospital of Peoples' Liberation Army
Prof. Spector, MIT
Prof. Spector, MIT |
Report due |
| 13 |
Federal Regulatory Issues for Tissue Engineering Products in the U.S., China, and Other Countries
Brain Repair
Review |
Prof. Spector, MIT
Prof. Cui, Tsinghua University
Prof. Spector, MIT / Prof. Cui, Tsinghua University |
Homework 4 due |
| 14 |
Quiz 2 |
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