All reading assignments are from the following textbook:
Crews, Phillip, Jaime Rodríguez, and Marcel Jaspars. Organic Structure Analysis. New York: Oxford University Press, 1998. ISBN: 0195101022.
| 1 |
Molecular Formula and Index of Hydrogen Deficiency (EA and MS) |
Ch. 1 |
| 2 |
Molecular Formula and Index of Hydrogen Deficiency (EA and MS) (cont.) |
Ch. 6.1-4 |
| 3 |
Functional Groups (IR, MS Fragmentation) |
Ch. 6.5-8, Ch. 8 |
| 4 |
Functional Groups (13C NMR) |
Ch. 2 |
| 5 |
Connectivity (1H NMR): J Coupling |
Ch. 4.1-7 |
| 6 |
Connectivity (1H NMR): The Chemical Shift; MS Fragmentation |
Ch. 3 |
| 7 |
Structure Determination (Examples) |
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| 8 |
Structure Determination (Examples) (cont.) |
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Exam 1 |
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| 9 |
1D Decoupling: 1H-1H, DEPT/APT/INEPT |
Ch. 4.8, 5.1-3 (See also Ch. 4.8, 4.10) |
| 10 |
2D Decoupling: HMQC, HMBC, HSQC, INADEQUATE |
Ch. 5.4-9 |
| 11 |
nOe, NOESY, ROESY |
Ch. 4.9, 5.4-9 (See also Ch. 2.6) |
| 12 |
Other Nuclei (NMR); MS: EI, CI, FAB, Negative Ion Modes, MALDI |
Ch. 2.2, 7.1-4 |
| 13 |
MS: GCMS, LCMS (APCI, Electrospray),(MS)n |
Ch. 7.5-8 |
| 14 |
Determination of Configuration (X-ray, CD, Derivitization) |
Ch. 9 |
| 15 |
Structure Determination, Examples |
Ch. 10 and 11 |
| 16 |
Determination of E.e. ([α]D, Shift Reagents, Chromatography) |
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Exam 2 |
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