| 1 |
Molecular Formula and Index of Hydrogen Deficiency (EA and MS) |
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| 2 |
Molecular Formula and Index of Hydrogen Deficiency (EA and MS) (cont.) |
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| 3 |
Functional Groups (IR, MS Fragmentation) |
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| 4 |
Functional Groups (13C NMR) |
Problem set 1 due |
| 5 |
Connectivity (1H NMR): J Coupling |
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| 6 |
Connectivity (1H NMR): The Chemical Shift; MS Fragmentation |
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| 7 |
Structure Determination (Examples) |
Problem set 2 due |
| 8 |
Structure Determination (Examples) (cont.) |
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Exam 1 |
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| 9 |
1D Decoupling: 1H-1H, DEPT/APT/INEPT |
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| 10 |
2D Decoupling: HMQC, HMBC, HSQC, INADEQUATE |
Problem set 3 due (Three days after lecture 10) |
| 11 |
nOe, NOESY, ROESY |
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| 12 |
Other Nuclei (NMR); MS: EI, CI, FAB, Negative Ion Modes, MALDI |
Problem set 4 due |
| 13 |
MS: GCMS, LCMS (APCI, Electrospray), (MS)n |
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| 14 |
Determination of Configuration (X-ray, CD, Derivitization) |
"Structure Elucidation of Unknown Compound" project due |
| 15 |
Structure Determination, Examples |
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| 16 |
Determination of E.e. ([α]D, Shift Reagents, Chromatography) |
Problem set 5 due |
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Exam 2 |
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