| 1 |
Introduction of Instructor and Students
Overview and Discussion of the Syllabus
Aim of the Course
How to Read a Scientific Paper
Literature and Database Searching
Introduction to Next Week's Topic |
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| Part I: Defense Mechanisms Developed by Unicellular Organisms |
| 2 |
Recognition of Foreign Nucleic Acids
The Restriction/Modification (R-M) System |
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| 3 |
Recognition of Foreign Nucleic Acids
RNAi |
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| 4 |
Anti-microbial Peptides |
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| 5 |
Altruistic Death |
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| Part II: The Transition to Multi-Cellularity Resulted in Cell Specialization |
| 6 |
How are pathogens recognized by multi-cellular organisms?
Pattern Recognition and Missing Self |
Assignment 1 due |
| 7 |
How do multi-cellular organisms destroy pathogens?
Phagocytosis |
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| 8 |
How do multi-cellular organisms destroy pathogens?
Complement and Reactive Oxygen |
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| Part III: An Evolutionary Milestone: The Origin of an Adaptive Immune System |
| 9 |
Receptors of the Adaptive Immune System
Antigen Recognition by Cells of the Adaptive Immune System Involves the Major Histocompatibility Complex (MHC) |
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| 10 |
Clonal Selection and Immunological Memory |
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| 11 |
How does the adaptive immune system interact with the innate immune system? |
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| 12 |
Change or Die |
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| 13 |
Student Oral Presentations
Course Evaluations |
Assignment 2 due |