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Assigned readings are from the course text:
Watson, James D., Tania A. Baker, Stephen P. Bell, Alexander Gann, Michael Levine, Richard Losick. Molecular Biology of the Gene. 5th ed. San Francisco, CA: Pearson/Benjamin Cummings, 2003. ISBN: 9780805346350 .
Course readings.
| Lec # |
Topics |
Readings |
| 1 |
Replication (Replication Enzymes) |
Watson, pp. 181-194. |
| 2 |
Replication (Replication Fork) |
Watson, pp. 195-212. |
| 3 |
Replication (Prok. System) |
Watson, pp. 212-221. |
| 4 |
Replication (Euk. Systems) |
Watson, pp. 212-221. |
| 5 |
Chromatin Assembly |
Watson, pp. 151-165 and 222-233. |
| 6 |
DNA Mismatch Repair |
Watson, chapter 9. |
| 7 |
DNA Repair II |
Watson, chapter 9, pp. 246-257. |
| 8 |
DS Break Repair
Homologous Recombination |
Watson, chapter 10, pp. 259-268. |
| 9 |
Homologous Recombination Enzymes |
Watson, chapter 10. |
| 10 |
Meiotic Recombination |
Watson, chapter 10. |
| 11 |
Site-specific Recombination |
Watson, chapter 10, pp. 293-310. |
| 12 |
Transposition |
|
| 13 |
Transcription: Prok. Machinery and Promoters |
|
| 14 |
Transcription: Euk. Machinery and Promoters |
Watson, chapter 12, pp. 347-363. |
| 15 |
Transcription: Regulation I |
Watson, chapter 16, pp. 483-504. |
| 16 |
Transcription: Regulation II |
Watson, chapter 12 and 17, pp. 363-377 and 529-551. |
| 17 |
RNA Processing I |
Watson, chapter 12 and 17, pp. 363-377 and 529-551. |
| 18 |
RNA processing II |
Watson, chapter 13. |
| 19 |
RNA Processing: Regulation |
Watson, chapter 13. |
| 20 |
RNA Editing
RNAi and miRNAs |
Watson, chapter 13, pp. 563-565. |
| 21 |
Translation: Basic Machinery I |
Watson, chapter 14, 16 and 17, pp. 411-454, 504-511 and 565-567. |
| 22 |
Translation: Basic Machinery II |
Watson, chapter 14, 16 and 17, pp. 411-454, 504-511 and 565-567. |
| 23 |
Translation: Regulation I |
Watson, chapter 14, 16 and 17, pp. 411-454, 504-511 and 565-567. |