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Text
Yannas, I. V. Tissue and Organ Regeneration in Adults. New York, NY: Springer, 2001. ISBN: 9780387952147.
| I. Tissue Environment of the Implanted Biomaterial: Unit Cell Processes |
| L1 |
Survey of Clinical Cases of Biomaterials-Tissue Interactions |
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Survey of Clinical Cases of Biomaterials-Tissue Interactions: The Paradigm (PDF) |
| L2 |
Tissue Structures, Unit Cell Processes, and Integrins |
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Giancotti, F. G., and E. Ruoslahti. "Integrin Signaling." Science 285 (13 Aug 1999): 1028-1032.
This paper presents the concept of integrin signaling.
Ruoslathi, E., and M. D. Pierschbacher. "New Perspectives in Cell Adhesion: RGD and Integrins." Science 238, no. 4826 (23 Oct 1987): 491-497.
This paper describes the discovery of an amino acid sequence that is a ligand for integrins.
Working/Operational Definitions (PDF)
Tissue Structure/Unit Cell Processes (PDF) |
| L3 |
Unit Cell Processes Comprising the Healing Response |
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| L4 |
Irreversible Healing Behavior of the Extracellular Matrix (ECM) of Organs |
Chapters 1-4 |
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| L5 |
Biochemistry of the ECM |
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Extracellular Matrix Molecules (PDF) |
| L6 |
Scaffolds Based on ECM Analogs Used in Organ Synthesis |
Chapter 8 |
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| L7 |
Organ Replacement by Induced Regeneration and Tissue Engineering |
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| L8 |
Principles and Practice of Tissue Engineering |
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| E1 |
Quiz 1 |
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| II. Physicochemical Interactions at the Surface of Biomaterials and Signaling within Tissue |
| L9 |
Characteristics of the Surfaces of Biomaterials |
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Characteristics of the Surfaces of Biomaterials (PDF) |
| L10 |
Methodology for the Analysis of Surfaces |
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Ratner, B. D. "Surface Properties of Biomaterials." In Biomaterials Science. Edited by B. D. Ratner, et. al. Burlington, MA: Academic Press, 1996. ISBN: 9780125824606.
Methodology for Chemical Analysis of Surfaces (PDF) |
| L11 |
Physicochemical Principles of Protein Adsorption on Solid Surfaces |
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Andrade, J. D. "Principles of Protein Adsorption." In Surface and Interfacial Aspects of Biomedical Polymers. Vol. 2. Edited by J. D. Andrade. NY: Plenum Press, 1985.
Chinn, J. A., et. al. "Postadsorptive transitions in fibrinogen adsorbed to polyurethanes." Journal of Biomedical Materials Research 26 (1992): 757-778.
Rapoza, R. J., and T. A. Horbett. "Postadsorptive transitions in fibrinogen: Influence of polymer properties." Journal of Biomedical Materials Research 24 (1990): 1263-1287. |
| L12 |
Protein/Cell/Tissue-Biomaterials Interactions |
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| L13 |
Linear vs. Cooperative Cell-Matrix Interactions |
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| L14 |
Cell-Matrix Interactions During Spontaneous Healing |
Chapter 9 |
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| L15 |
Contraction-Blocking Theory of Regeneration in Adults |
Chapters 8 and 10 |
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| E2 |
Quiz 2 |
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| III. In Vivo and Clinical Case Studies |
| L16 |
Joints and Dental Tissues: Prosthetic Replacement |
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Joints: Regeneration of Bone, Cartilage, Meniscus, Ligament, and Tendon (PDF) |
| L17 |
Joints and Dental Tissues: Regeneration 1 |
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| L18 |
Joints and Dental Tissues: Regeneration 2 |
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| L19 |
Epithelialization (Epidermal Regeneration) and Endothelialization of Vascular Prostheses |
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| L20 |
Rules for Synthesis of Tissues and Organs |
Chapter 7 |
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| L21 |
In Vivo Synthesis of Skin |
Chapter 5 |
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| L22 |
In Vivo Synthesis of Peripheral Nerves |
Chapter 6 |
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| L23 |
In Vivo Synthesis of the Conjunctiva and of Kidney Tissue |
Chapter 8 |
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| E3 |
Quiz 3 |
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